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8 The patch is a long-acting delivery method that delivers a steady amount of nicotine to pass, from the patch, through the skin, directly to the blood with immediate transport to the brain

Smokers are nearly twice as likely to have a heart attack as non-smokers

Psychopharmacology 191 , 159169 (2007)

Signs include strong cravings, using more nicotine over time (tolerance), irritability or anxiety without it, difficulty quitting, and continued use despite health or social problems

It also raises dopamine levels, a neurotransmitter in the brains reward system responsible for pleasure and reward sensations

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