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Treatment facilities that allow smoking or vaping may have rules about this

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This is important because standard PD-L1 thresholds such as 1% or 50% may not fully capture the subgroup most likely to benefit in never-smokers

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It's quite possible the CSM at some point underwent a procedure to give him a kind of healing factor, perhaps one that would enable him to be found in the river a bit after he was shot, recovered, and restored to health