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This may contribute the COPD pathology, inducing apoptosis, tissue damage as well as airway inflammation, since airway epithelial cells respond to increased ROS levels by producing cytokines/chemokines that attract inflammatory cells to the area of damage [5, 6, 21, 23, 24]

The talk goes on for hours

Theres no real mention of how the other ingredients blend with the tobacco

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Several aldehydes, including formaldehyde, methylglyoxal (MGO), and glyoxal (GO), were found at significantly higher concentrations in heavily used devices