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doi: 10.1096/fj.201500109R 250 KawaiMHagiharaKHiranoTShimaYKuwaharaYArimitsuJet al

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REDEFINE-1 trial dosing protocol Study design: Duration: 68 weeks Participants: Adults with obesity (BMI 30) Arms: CagriSema vs semaglutide 2.4mg vs placebo Pre-filled combination pen (not separate injections) Fixed-dose weekly administration Primary endpoint results: Key findings: 50% more weight loss than semaglutide alone Superior to either peptide used individually Synergistic not merely additive effect Higher side effect rate but manageable Most participants tolerated full doses Learn the science at SeekPeptides - explore what are peptides , how peptides work , and peptides for weight loss

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