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Coord Chem Rev, 2022, 454: 214330 Wang Y, Yue C, Zhang M, et al

Surface charges influence the genotoxicity of liposomes, with positively charged nanocarriers exhibiting reduced genotoxicity

10.1007/s12192-016-0693-5 89

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The main outcome measures, monitored every 3-6 months, were linear growth enhancement (height velocity), bone age progression, and safety measures including clinical chemistry

The injection site typically shows localized redness and itching that resolves within 24 to 48 hours, distinct from systemic autoimmune rash patterns