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The effects of abnormal esophageal contractions would be expected to be worse at night when gravity is not helping to return refluxed acid to the stomach

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PLoS One 3:e3316 Kim HP, Wang X, Chen ZH, Lee SJ, Huang MH, Wang Y, Ryter SW, Choi AM (2008) Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1

Exposure to secondhand smoke, which occurs when people inhale smoke exhaled by people who smoke or from burning tobacco products, can cause cancer

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