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(Science-Based Medicine) Potential thyroid, kidney or metabolic disturbances some anecdotal reports and reviews raise these as possible but under-studied risks

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Amandine Grimm, University of Basel, Switzerland Updates Copyright 2019 Braidy, Zarka, Jugder, Welch, Jayasena, Chan, Sachdev and Bridge

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Among the clotting time measures, mPT was the most sensitive to the effects of apixaban with a mean maximum increase from the baseline of approximately 226%229%, following administration of a 50 mg single dose, and exhibited a steeper concentrationresponse relationship than that for INR, which exhibited approximately a 50%64% increase at the 50 mg dose (Figures 3, S1, and S2 and Tables S1 and S2)