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Liver-on-a-chip integrated with label-free optical biosensors for rapid and continuous monitoring of drug-induced toxicity

Overall, the resolvable range of the Ycf1 R-domain coincides with the region containing the highest sequence conservation to CFTR, which possesses a longer R-domain than Ycf1 but otherwise conserved kinase motifs (Fig

Based on available evidence, SCFAs exert protective effects by activating the Nrf2/GPX4 pathway to inhibit lipid peroxidation, while LPS acts through the dual mechanisms of suppressing the antioxidant defense system (GPX4) and disrupting iron metabolic homeostasis

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Jing Ai, Shanghai Institute of Materia Medica (CAS), China Updates Copyright 2020 Shao, Pan, Tu, Zhang, Yan and Shao