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(B) The pattern was deemed to be present if the lesion satisfied all three of the following features

Deficiencies in carnitine disrupt several metabolic pathways, including amino acid metabolism, beta-oxidation (fat burning) and the Krebs cycle

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Sousa, L., Oliveira, M

B12 bound to HC is not taken up by cells and thus, is biologically inactive ( via endocytosis using a specific CD320 receptor ( via CblF ( This free cytoplasmic B12 undergoes a series of intracellular transport and modifications to enable two core enzymatic reactions: 1) adenosyl-B12 acts as a co-factor for the enzyme methylmalonyl-coA mutase that catalyzes the conversion of methylmalonyl-coA to succinyl-coA, thereby enabling restoration of tricarboxylic acid (TCA) cycle intermediates and 2) methyl-B12 enables methionine synthase in the re-methylation of homocysteine to methionine using methyl-tetrahydrofolate (MTHF) as a methyl donor, thereby enabling the vital biochemical pathways of the folate cycle and methionine cycle, facilitating the downstream synthesis of important compounds like DNA and RNA (Figure 2)

The COA included endotoxin and sterility data which our lab requires. Both batches came well within TFA acceptable limits