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Symptoms of a deficiency can be vague and include fatigue, weakness, a tingling sensation or numbness in your hands and feet, and memory problems

Kumar RR, Singh L, Thakur A, Singh S, Kumar B (2022) Role of vitamins in neurodegenerative diseases: a review

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Many people report improved mood, reduced symptoms of depression and anxiety, and better cognitive function after B12 supplementation

Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available