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If nausea or constipation remains severe after two weeks at your current dose, your clinician may recommend pausing for one week before resuming at the same dose, or temporarily lowering your dose to allow more gradual adaptation

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Some studies have suggested that excluding participants who had gastroenteritis prior to the first use of PPIs or correcting for confounding factors, such as susceptibility and time dependence of bacterial gastrointestinal infections, can remarkably reduce the association between PPI treatment and bacterial gastroenteritis (Garcia Rodrguez and Ruigmez, 1997