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However, if the toxic or injurious insult persists, GCLC expression may become dysregulated

Link Zhou, X., Li, Q., Wang, Y., & Zhang, D

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Inflammatory mediators released during infection and surgical stress (e.g., IL-6, IL-10) can remodel hepatic and cutaneous immune microenvironments, thereby amplifying drug toxicity

These effects are mediated in part by stress-responsive transcription factors that coordinate the expression of genes involved in GSH metabolism and redox control

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