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[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed

Physical therapy then guides patients through progressive strengthening and stretching exercises

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10.1016/j.ajhg.2013.07.022 Summary Keywords cobalamin, hydroxocobalamin, cyanocobalamin, vitamin B12, metabolic Citation Elangovan R and Baruteau J (2022) Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation