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Nasal Sprays and Patches Non-invasive alternatives, with effects developing over several days to a week

But three things limit what these animal studies can tell us

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References: Goulian, A

Modules correlated with the KO genotype were enriched for neuronal and synaptic genes involved in vesicle-mediated transport, neurotransmitter secretion, and GTPase activity, suggesting that RAMP deletion disrupts synaptic signaling networks critical for metabolic regulation [2]