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Modifiable risk factors include smoking , high cholesterol , high blood pressure , lack of exercise , obesity , high stress levels , unhealthy diet , heavy alcohol consumption , and poor sleep quality

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doi: 10.3390/ijerph16162895 160 AL-MegrinWASolimanDKassabRBMetwallyDMAbdel MoneimAEEl-KhadragyMF

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These findings collectively indicate that alkaloid metabolites target the central node of the AMPK pathway, providing a multi-target intervention strategy for NAFLD treatment through a dual mechanism of inhibiting lipogenesis while promoting fatty acid oxidation