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Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation toward a neuroprotective role

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Polysubstance use, particularly the practice of cannabis and alcohol co-use, is established in the literature, and referred to by the term cross-fading 14 and this phenomenon has been extended to describe e-cigarette and alcohol co-use 15