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Personalization is crucial, yet factoring highly complex factors such as genetics, sex, metabolic rate, microbiome composition, socioeconomic status, circadian rhythms, and cultural influences remains challenging

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Toxicology 149:4350 Thomas C, Mackey MM, Diaz AA, Cox DP (2009) Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: implications for diseases associated with iron accumulation

It points to new avenues for developing targeted therapiessuch as molecules that can restore microexon inclusion or compensate for its absence