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10.1016/j.pneurobio.2005.10.005 102 MeguidN

doi: 10.1126/science.184.4140.952 73 BarryDMReeveAW

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In both occurrences, N-Acetyl-Cysteine (NAC) supplementation supplies the cysteine necessary for GSH synthesis and contemporarily reduces HHcy, improving the GPx1 activity and further reducing oxidative stress

PMID 19202056

These enzymes form a multienzyme metabolic complex, which translocates to the nucleus during S (DNA replication) and G2/M (DNA damage checkpoint) phases, and is required for biosynthesis of the nucleotide precursor, thymidylate, which is critical to DNA synthesis and repair