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ACKNOWLEDGEMENTS We thank Lorenza Lanini and Ray Hill, independent medical writers acting on behalf of Springer Healthcare Italy, who provided medical writing support, and Tracy Harrison, of Springer Healthcare Communications, who provided editorial assistance post submission

revealed that while transient skin-benefitting results were seen in 37.5% of patients with IV glutathione (1200 mg twice weekly for six weeks), 32% developed adverse events, again revealing a large risk-to-benefit ratio imbalance

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