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Final Results of A Phase 1 Study Investigating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Quizartinib (AC220) Administered Daily to Patients with Relapsed or Refractory Acute Myeloid Leukemia Irrespective of FLT3-ITD Status

Hematologic changes and serum B12 rise over weeks to months

The scheduling must be set on the first appointment

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Future clinical research on flavonoids should prioritize larger sample sizes, longer follow-up durations, and multi-center study designs to enhance statistical power and generalizability