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Anti-diabetic drugs (such as thiazolidinedione) have similar effects and all of these drugs are well documented as being linked to obesity in humans by activating PPARy receptors.[18,19,20,21,22,23] The same receptors activated by the aforementioned obesogens in animals and thus many researchers believe that they would have the same effect in humans.[13] One of the earliest observations of an obesogenic effect from chemical exposure in humans came from studies of exposure to secondhand smoke in utero