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Nrf2 knockout also resulted in further down-regulation of GSH, GCL, l-Glutamic acid and pyroglutamylglycine compared to WT mice (Fig

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Among these, skeletal muscle wasting is a critical consequence of inactivity and around 20% of COPD patients suffer from severe skeletal muscle wasting, which leads to considerable morbidity and mortality [61]

Hydrogen cyanide (HCN)

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