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Field KM, Simes J, Nowak AK, Cher L, Wheeler H, Hovey EJ, et al

ACTH then acts on the inter-renal cells in the head kidney (the functional equivalent of the adrenal cortex in mammals), triggering the release of cortisol into the bloodstream

Originally identified during investigations involving sleep physiology and neurological regulation, DSIP peptide has attracted substantial scientific interest due to its unique structure and potential interactions with biological systems associated with sleep cycles and neuroendocrine signaling

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To this day, several clinical trials are ongoing in a large panel of age-related diseases, but their validation remains uncertain (Table 1)