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3 Mammalian CHAC2: defining its role in glutathione homeostasis, cancer progression and stem cell fate In addition to CHAC1, which is found exclusively in higher eukaryotes, organisms from bacteria to mammals possess a CHAC2 enzyme that exhibits a highly similar glutathione-specific GCT activity (Kaur et al., 2017)

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Oregon State University - Linus Pauling Institute Accessed October 29, 2025

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