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Regulation of ferroptotic cancer cell death by GPX4

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A study with the angiotensin II type 1 receptor blocker, azilsartan, demonstrated that the neuroprotection against cisplatin-induced retinal and optic nerve toxicity was associated with reduced levels of TNF-, NF-kB and Caspase-3, but oxidative stress markers were not assessed (Raheem and Mohammed Ali Mahmood 2023)

In the research by Wen et al

As a consequence, the unrestrained and potentially lethal accumulation of ROS threatens to damage many biomolecules: lipids, proteins, DNA, and host cells