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accordingly, a divided dose of two times 100 milligrams, both with meals, will result in better absorption than a single 200-milligram dose taken with a meal (Singh 2005)

However, the trial was discontinued due to the drugs limited therapeutic efficacy and poor bioavailability

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An important methodological difference between the two studies is that Bartnik-Olson and colleagues had a healthy, non-injured comparison group whereas our study had an OI comparison group

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Human studies have mainly described pharmacokinetics, safety, and tolerability, rather than demonstrating strong clinical effectiveness