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usually most pronounced during dose escalation Diarrhea : Affects 12-17% of patients, typically mild to moderate in severity Vomiting : Reported in 6-10% of patients, more common at higher doses Constipation : Occurs in 6-11% of patients Abdominal pain and dyspepsia : Generally transient Decreased appetite : An expected pharmacological effect contributing to weight loss Other documented adverse effects include injection site reactions, hypoglycemia (when used with insulin or sulfonylureas), and less commonly, fatigue

Worthington DJ, Rosemeyer MA (1976) Glutathione reductase from human erythrocytes

Calms irritation, reduces redness, and accelerates healing after procedures

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Tb-500 binds to G-actin, the building block form of these proteins, preventing premature polymerization into rigid filaments

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