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10.1016/j.bbagen.2012.10.005 Biochim Biophys Acta

A larger study (SEMA-NASH) enrolling 320 individuals with obesity, biopsy-proven NASH and different degrees of fibrosis, with or without diabetes, demonstrated that OD subcutaneous semaglutide 0.4 mg significantly resolved MASH without worsening fibrosis in 59% of patients 93

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Engineering a diverse ligase toolbox for peptide segment condensation