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L.NegreanV.et al (2020)
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Conventional oral glutathione is broken down into its constituent amino acids before reaching the bloodstream, delivering negligible intracellular GSH elevation
[30]Kalinhoff C, Caldern NT
To further examine the role of the signal peptide in PLA2G2F expression, we generated two constructs with mutations in the signal peptide: PLA2G2F(L53V57) (SP_), which has a shorter ER transmembrane H region of the peptide and is predicted to fail ER targeting, and PLA2G2F(A61Y/G63Y) (SP_YY), which harbors substitutions of two residues at the predicted cleavage site of the signal peptide 37
Since glutathione and taurine share the same precursor, taurine synthesis may affect GSH synthesis which can increase the oxidative damages induced by overuse of muscles
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