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Additionally, the dual regulatory mechanism of Tan IIA, which enhances chemosensitivity in tumor cells while protecting cardiomyocytes, necessitates a high degree of in vivo targeting specificity (40)

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Biol Trace Elem Res 76(2):161173

Disabling glycolysis with 2-deoxy-D-glucose or silencing SOX9 eliminates these malignant traits in vitro and sharply limits xenograft growth in vivo, underscoring that the hypoxia-induced glycolysislactateSOX9 lactylation cascade sustains tumor aggressiveness and positions both lactate production and SOX9la as promising therapeutic targets in NSCLC [193]

Water kefir and derived pasteurized beverages modulate gut microbiota, intestinal permeability and cytokine production in vitro

Figure 4 2.3.4 The gut microbiome in ALS pathogenesis Recent studies have shown that the gut microbiome, the community of bacteria living in our digestive system may play an important role in the development and progression of ALS