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1 Introduction The immune response against pathogens and non-pathogens is regulated by key signaling pathways

10.1016/j.canlet.2017.05.010 237 RasinarA.-D.MoraruD.LazrR.PtruicS

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Biomolecules 10 , 358, (2020)

IL-1 is known to directly induce fatigue and malaise through stimulating the hypothalamic-pituitary-adrenal axis and inflammatory signaling pathways in the central nervous system (CNS) [35, 36]