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Once crystalized, uric acid activates the immune system 3,4 , since it acts as a pro-oxidant molecule that reduces nitric oxide availability 1 , increases the production of reactive oxygen species (ROS), stimulates chemotaxis and also activates NF-B and MAPK pathways 1

And understanding that gap determines whether an accidentally exposed vial gets discarded or simply returned to proper storage

doi: 10.1172/JCI137556

2011 doi: 10.1186/1758-5996-3-31

The main difference is how and how often theyre taken