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Wang SY, Fu XX, Duan R, Wei B, Cao HM, Yan E, et al
A variety of assays were used to measure serum, plasma, and intracellular GSH in MCI and AD populations, including assays using DTBN [36,37,38, 44, 48,49,50, 56,57,58,59], OPA [39, 40, 45, 52, 61], high performance liquid chromatography [42, 43, 46, 51, 53, 55], enzyme-linked immunosorbent assays [69], and other commercial assay kits [60, 62]
Another study by Suter et al
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These properties include: Aqueous solubility (which affects dissolution) Stability in the acidic environment of the stomach and enzymatic environment of the intestine, Molecular size , and pKa (which determines its ionization state and ability to cross lipid membranes) 12 Dosage Form and Formulation: The design of the drug product can significantly impact bioavailability
Smallmolecule ferroptosis inhibitors and natural compounds show efficacy but are constrained by poor pharmacokinetics and bioavailability
