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In some embodiments, the otoprotectant is a compound of Formula (XI): wherein: R 1 is C 6 -C 10 aryl or C 3 -C 9 heteroaryl, wherein C 6 -C 10 aryl and C 3 -C 9 heteroaryl are optionally substituted with one or more R 4

Concentrations decline sharply with age: plasma levels drop from roughly 200 ng/mL at age 20 to under 80 ng/mL by age 60

Flip the vial upside down while keeping needle inserted

That said, the animal research is genuinely interesting and points toward several areas worth continued investigation

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Fever, chills, and redness, pus or spreading warmth at the site can indicate cellulitis or a bloodstream infection and need medical attention