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In practice, a researcher selecting between them is usually choosing which mechanistic question to probe: vascular and cytoprotective signaling points toward BPC-157, while questions dominated by cell migration and cytoskeletal dynamics point toward TB-500

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Steric hindrance from the increased side-chain volume of E14 Cagri and R17 Cagri promotes a shift of the -helix of Cagri away from ECL2 and a slight expansion of the peptide binding pocket at the extracellular side of the CTR TM domain, relative to those observed with rAmy/San385-bound AMYR complexes