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therefore, EDCs may directly influence hormone action only in these tissues

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Alterations in methylation patterns are also a fundamental mechanism for epigenetic modifications, allowing for transgenerational effects

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Consistent with its role in regulating mGSH, mitochondrial cholesterol accumulation emerges as a key factor regulating ROS and electrophile detoxification, and hence disease progression by sensitizing to secondary hits such as TNF, hypoxia or toxic amyloid peptides