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3.5 Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship

Participants showed significant reductions in waist circumference, systolic and diastolic blood pressure, glycated hemoglobin, fasting glucose, insulin levels, and lipid profiles

Neither agent is currently approved for routine clinical use in the UK, and both remain under active investigation

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