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(4) Patients with confirmed resistance to entecavir or reduced glutathione, as evidenced by prior treatment failure, documented drug resistance mutations, or lack of clinical response to these drugs in past therapies

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Glutathione activates the Nrf2/HO-1 signaling pathway, a critical transcriptional regulator of antioxidant gene expression

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Congenital leptin deficiency due to homozygosity for the 133G mutation: report of another case and evaluation of response to four years of leptin therapy