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Although hepatitis has been observed with extended-release nicotinic acid at dosages as little as 500 mg/day for two months, almost all reports of severe hepatitis have been associated with doses of 3 to 9 g/day used to treat high cholesterol for months or years (41)

Taking short breaks between pouches and good oral hygiene can help avoid persistent irritation

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But while it eased some problems, it created others

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