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CAR T cells were manufactured from isolated T nave/memory (Tn/mem) cells as previously described 3

Pain 160 (12), 28772890

Cancer Letters , 474 , 138150

The antioxidant role of selenium is generally linked to its presence at the active centre of enzymes that are redox catalysts, of which the best known are GSH peroxidase which removes H 2 O 2 and lipid peroxides, and thioredoxin reductase which is homologous to GSH reductase and critical for redox regulation of protein function and signalling (4)

First of all, intracellular iron generally exists in the form of Fe 2+ , which can produce OH through the Fenton reaction, and then react with polyunsaturated fatty acids in the plasma membrane to produce ROS, resulting in iron-regulated death