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Anytime patients tell me they have a reaction from taking B vitamins, like nausea or some kind of digestive symptom, I automatically think that they might have some microbial issue

Researchers have proposed that the peptide may influence dermal remodelling through regulation of collagen synthesis, extracellular matrix organisation and restoration of skin barrier function

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Apoptotic bodies and released damage-associated molecular patterns (DAMPs) further stimulate inflammatory signaling in surrounding tissues, promoting joint-wide degeneration (Takada et al., 2011)

Other reviews uncovered similar limitations: For musculoskeletal injuries, the studies in people are too sparse and low quality to pin down whether the peptide works or what risks it poses