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Neuroscience and Cognitive Health: Researching its effects on the pineal gland and neuroendocrine factors can enhance understanding of cognitive aging and neuroprotection, with implications for neurodegenerative disease studies

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Similar to neuronal nuclear inclusions, the axonal ATXN3 aggregates were ubiquitinated and immunopositive for the proteasome and autophagy-associated shuttle protein p62 [23, 30], strengthening the involvement of neuronal protein quality control (PQC) mechanisms in the management of this mutant protein

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