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Recently, Singer et al

It activates the Nrf2 signaling pathway, decreases MDA and cyclooxygenase-2 (COX-2) expression, increases GSH, GPX4, and SLC7A11, inhibits blood creatinine and urea nitrogen retention caused by renal ischemia-reperfusion injury, thus ameliorating renal pathology (189)

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Even though experimental and observational studies show a significant correlation between elevated levels of plasma TMAO and adverse cardiovascular events, the precise mechanism is still in place and unidentified [11]

British Journal of Ophthalmology, 1994

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