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Bupropion requires dose reduction or avoidance in significant hepatic impairment and is contraindicated in people with a history of seizures

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Cigarette smoking is the leading cause of preventable death in the U.S., accounting for more than 440,000 deaths annually

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Medical Conditions Overall, many medical conditions may also impact our ability to sleep, including chronic pain, asthma/chronic pulmonary disease, arthritis, diabetes, heart disease, gastrointestinal problems, to name a few