NNMT (nicotinamide N-methyltransferase) is a cytosolic enzyme that catalyzes a specific methylation reaction: it transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing two products 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)
[1] NNMT as a Metabolic Research Target Independent research groups have studied NNMT inhibition in diet-induced obese (DIO) mouse models
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By inhibiting the NNMT enzyme, 5-Amino-1MQ promotes the bodys ability to burn fat more efficiently, which could lead to improved cellular health and a more youthful metabolic profile
All protocols, dosages, and treatment insights referenced herein are based on published literature
Subsequently, for these data as well as the alpha diversity analyses, each treatment group (within each phylum or genus for the relative abundance data) was analyzed for normal distribution (ShapiroWilk test) and the data across groups were tested for homoscedasticity (BrownForsythe test)